Fiber feature map based landmark initialization for highly deformable DTI registration

Fiber feature map based landmark initialization for highly deformable DTI registration

Gupta, Aditya and Toews, Matthew and Janardhana, Ravikiran and Rathi, Yogesh and Gilmore, John and Escolar, Maria and Styner, Martin

Medical Imaging 2013: Image Processing 2013

Abstract : This paper presents a novel pipeline for the registration of diffiusion tensor images (DTI) with large pathological variations to normal controls based on the use of a novel feature map derived from white matter (WM) fiber tracts. The research presented aims towards an atlas based DTI analysis of subjects with considerable brain pathologies such as tumors or hydrocephalus. In this paper, we propose a novel feature map that is robust against variations in WM fiber tract integrity and use these feature maps to determine a landmark correspondence using a 3D point correspondence algorithm. This correspondence drives a deformation field computed using Gaussian radial basis functions(RBF). This field is employed as an initialization to a standard deformable registration method like demons. We present early preliminary results on the registration of a normal control dataset to a dataset with abnormally enlarged lateral ventricles affected by fatal demyelinating Krabbe disease. The results are analyzed based on a regional tensor matching criterion and a visual assessment of overlap of major WM fiber tracts. While further evaluation and improvements are necessary, the results presented in this paper highlight the potential of our method in handling registration of subjects with severe WM pathology. © 2013 SPIE.